To patch MSDE running with Microsoft Application Center 2000, you need to install a version of MSDE Service Pack 2 which is specifically intended to be used with Application Center.
In order to patch MSDE running with Microsoft Application Center 2000, you need to install a version of MSDE Service Pack 2 which is specifically intended to be used with Application Center. More information on the Application Center specific version on MSDE 2000 Service Pack 2 is available in Microsoft Knowledge Base article Q813115.